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Barriers to gene delivery using synthetic vectors.

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❶The examples included a polyanion, PAA and a polycation, polyvinylpyridine, as well as other polyelectrolytes. Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the body that affect signal transduction mechanisms involved in inflammation, differentiation, proliferation, and apoptosis.

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Polymer Genomics: An Insight into Pharmacology and Toxicology of Nanomedicines

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